The intestines disease treatment prevails in Europe but still tried to find out

The intestines disease treatment prevails in Europe but still tried to find out
It is still a mystery to this time bring Model O104H4 Escherichia coli that infects in Germany by a large scale suddenly for medical circle. Though the genetic code of germ decode basically already, people for the moment difficult to describe in terms of science of making system in pathogenic mechanism in it. In the face of the complicated and rare course of disease, the doctors can only try to find out and move ahead, the clinical treatment of one month has offered many clues for scientific circles.
It will generally cause belly angina, diarrhoea, bleeding diarrhoea that infect common enterorrhagia Escherichia coli, heavy and causes the kidney to damage. But cause the pathogen of this epidemic situation except causing the above-mentioned symptoms, causes nerve problems of Germany's half the many patients.
What scientific circles wanted to find out about at present most is, why is toxicity of Escherichia coli of Model O104H4 so great? The little biologists of the medical university of Austrian Ince Brook link the thatch and is received and thought, destruction of pathogen this strength loud perhaps because it can produce more toxin in the human body, because it is stronger to the sticking of the enteric wall.
Scientific circles has morrhage Escherichia coliteric wall. Germany doctor of Hamburg find to the intersection of death and dissection of patient numerous germ assemble, stick, form phenomenon of the biomembrane together in large intestine too. The expert explains, the bacterium knows " unity is the strength " like people too ,Through " unite " The ones that formed bacterium's biomembrane and produced to antibiotic more easily were able to bear nature.
According to participating in linking the thatch and receiving the introduction of clinical treatment, new knowledge that epidemic situation bring to people this enterorrhagia will that Escherichia coli produce congratulate a kind of toxin, injure the kidney directly, also will make human immune system " The alexinic system " The response is too drastic, cause a large number of red blood cells to be destroyed. The alexinic system is a kind of very effective protection mechanism in the human body, the organism can destroy pathogen and tumour cell,etc. with it.
At present, many German hospitals try to inject monoclonal antibody Eculizumab for the patient, because this kind of antibody can prevent the too drastic response of the alexinic system. Not long ago, a pregnant woman's patient had already basically recovered after Germany reached the hospital and accepted the antibody treatment richly, the doctors have not found the side effect that the antibody treatment may bring on patient yet so far. However, this kind of antibody is curing enterorrhagia Escherichia coli and infects the respect and has not got the German official side to authorize, permit yet at present, take a large amount of to treat and verify its curative effect and side effect clinically even.
Link thatch, receive, point out antibody curative effect that treatment make so far seem, prove will congratulate kinds of toxin impact on immune system one important factor in pathogenic mechanism their, but people have no good plan to prevent the direct destruction of the kidney of toxin of this germ at present. In addition, the medical circle has not fully understood yet why this kind of toxin will cause so great influence on the central nervous system at present, cause patient appear forgetful, the intersection of language and obstacle, temporary the intersection of limb and the intersection of numb, twitching, shock,etc. and nervous system symptom.
As to this, the researchers of German Grife Sri Lankan Val Germany university and Bonn University provide a kind of explanation: Some value the intersection of disease and immune system of patient will produce, oppose normal antibody of cell in the one's own body. This kind " regards friend as enemies " Antibody might through factor of lasting one kind blood coagulation, lead to the fact whether there are insufficient in blood supply on brain and renal gland of patient, and then initiate the nervous system obstacle. Val of Grife Sri Lankan the intersection of Germany and doctor of city use one leach new treatment of blood to 4 serious the intersection of disease and patient the antibody already, the patient takes a favorable turn to some extent promptly in its state in one days after treating. But such experimental treatment needs to get more broad case to treat and examine.
At present, German to aim at, remove blood, poison plain blood, dialyse in standard treatment that patient adopt to serious disease in hospital. But some patients have not hesitated to already in early period accept the blood is dialysed in the course of disease, its neural state has not taken a favorable turn, some people's relevant condition is even worsening constantly.
At the beginning of epidemic situation, the German hospital is generally unwilling to adopt the antibiotic treatment, because discover antibiotic will cause enterorrhagia Escherichia coli to discharge more toxin, and the pathogen in this epidemic situation seems drug resistance is stronger. But because lacked the effective treatment, some hospitals of Germany used some special antibiotic to some patients boldly later, its theoretical foundation is to select antibiotic for use and can kill it under internal germ still few situations that will not discharge more toxin in right time. Some patients of a hospital of Hamburg accept really the state take a favorable turn after the antibiotic treatment, among them a patient has already left hospital.
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